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10.1002/1878-0261.13555 17 BugaziaD.Al-NajjarE.EsmailA.AbdelrahimS.AbboudK.AbdelrahimA.et al (2024)

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Their results demonstrated that sirolimus effectively suppressed tumor growth by inhibiting the mTOR signaling pathway, which plays a critical role in regulating cell proliferation, angiogenesis, and survival (200)

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Example dosage schedule Starting dose: 0.2 0.3 mg weekly for first 4-5 weeks Titration phase: 0.4 0.6 mg weekly for 4-5 weeks and then, if tolerated, 0.9 1.1 mg weekly for 4-5 weeks Maintenance dose for long-term weight management: 1.6 1.9 mg weekly for 4-5 weeks and then, if tolerated, 2.5 mg weekly (maximum dose) The dosage may vary depending on the individual needs, your initial BMI, and glycemic control

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